Effects of Anions and pH on the Determination of Diclofenac in Water Solutions by High Performance Liquid Chromatography

Yue ZHAO; Xiao-peng QIN; Fei LIU

doi:10.15898/j.cnki.11-2131/td.201704260067

Rock and Mineral Analysis > 2018 > 37(1): 79-86. > DOI: 10.15898/j.cnki.11-2131/td.201704260067

Yue ZHAO, Xiao-peng QIN, Fei LIU. Effects of Anions and pH on the Determination of Diclofenac in Water Solutions by High Performance Liquid Chromatography[J]. Rock and Mineral Analysis, 2018, 37(1): 79-86. DOI: 10.15898/j.cnki.11-2131/td.201704260067

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Effects of Anions and pH on the Determination of Diclofenac in Water Solutions by High Performance Liquid Chromatography

1.
Beijing Key Laboratory of Water Resources and Environmental Engineering, Key Laboratory of Groundwater Circulation and Environmental Evolution, Ministry of Education, China University of Geosciences(Beijing), Beijing 100083, China
2.
State Key Laboratory of Environmental Criteria and Risk Assessment, Soil Pollution Effect and Environmental Criteria, Chinese Research Academy of Environmental Sciences, Beijing 100012, China

More Information

Received Date: April 25, 2017
Revised Date: August 05, 2017
Accepted Date: September 03, 2017
Published Date: December 31, 2017

Abstract

Highlights
· The additions of SO₄^2- and Cl^- had no effect on the determination of diclofenac (DCF) in water.

· The presence of NO₃^- could lead to a red shift of maximum absorption wavelength of DCF.

· The peak height of DCF in acid medium was lower than the actual value.

ABSTRACT

Diclofenac (DCF) is one of the widely used non-steroidal anti-inflammatory drugs. With the increased production and consumption, DCF is frequently detected in the environment. DCF can be enriched in organisms and has potential toxicity to several organisms, causing much concern. The accuracy determination of DCF is the basis for other studies. In a previous study, pretreatment methods were always used to eliminate matrix effects during the measurement of DCF, but how the sample matrix influences DCF measurement was not studied in details. In order to meet the need of field sample measurement and laboratory research, the effects of common anions SO₄^2-, Cl^- and NO₃^-, solution pH, and mobile phase constitutions on the determination of DCF using High Performance Liquid Chromatography with the UV-Vis detector (HPLC-UV) were investigated. The results show that SO₄^2- and Cl^- had no effect on the maximum absorption wavelength of DCF (277 nm), but NO₃^- changed the maximum absorption wavelength of DCF (277 nm) and resulted in the red shift phenomenon. Under the same condition, the measured concentration of DCF by HPLC in acidic medium (pH < 5) was lower than that in an alkaline medium. Comparing with the peak area of DCF in alkaline medium (pH=7.26), the peak area of DCF in acidic medium (pH=2.01) decreased by 73.14%. Therefore, determination of DCF under alkaline conditions has greater accuracy.
- water environments,
- diclofenac,
- High Performance Liquid Chromatography,
- anions,
- pH,
- mobile phase

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References (34)

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