Abstract: The Nanling region, a famous W, Sn and rare-earth metallogenetic belt, is closely related to Mesozoic magmatic activities based on previous research work. There has been little research on the relationship between Caledonian granite and mineralization. The outcrop area of Caledonian granite in this region is slightly less than that of the Mesozoic granite and may be related with mineralization of W, Sn and rare earth elements (REEs). Based on field research, Laser Ablation-Multicollector Inductively Coupled Plasma-Mass Spectrometry (LA-MC-ICPMS) was applied to date the zircon from the Wantian granite. The W/Sn ratios from sediments and granites were compared in this area. The results show that the accurate diagenetic age of the Wantian granite is 464.9 Ma. From the Caledonian to Yanshanian eras, the enrichment of the ore-forming elements W/Sn has gradually increased, which hints that mineralization of the area may have some inheritance.