Abstract: A method has been developed for the determination of Mo, Cu, Pb, Zn, Ni, As and S in porphyry type lindgrenite from Tibet by Wavelength Dispersive X-ray Fluorescence Spectrometry with pressed powder pellets. The national standard reference materials of molybdenum ore and copper ore, as well as self-synthesized reference materials were used to build the working curve. Using Compton correction as the internal standard, the matrix effect and particle size effect was corrected by empirical coefficients. According to the verification by the national standard reference materials and self-synthesized reference materials, the analytical results were in good agreement with certified values. The relative standard deviation RSD (n=12) of this method was less than 2.18% for all of the elements. Compared with classical chemical methods, this method was simple, fast and highly accurate and provided precision without chemical pretreatment. It is suitable for practical determination of lindgrenite samples. Seven calibration samples were synthesized by the national standard reference materials which solved the problem of lack of calibration samples.