Abstract: A method was developed for the determination of fluorine and sulfur in glass by ion chromatography coupled with alkali fusion. The glass samples were calcined with solid NaOH in a muffle furnace at 700℃, then extracted by hot water. The extracted solution was loaded through the OnGuard Ⅱ Ag/H cartridges before being injected into the Ion Chromatography system in which fluorine and sulfur were separated by the Ionpac AG14 and AS14 column and detected by conductometry. The linear range for the determination of fluorine and sulfur were 0.1-2 μg/mL and 0.5-20 μg/mL with detection limits of 2.0 mg/kg and 1.0 mg/kg, respectively. The relative standard deviation was less than 5.0%. The results of Ion Chromatographic ethod and chemical method have no significant difference for the determination of glass samples.