Abstract: Geological standard glass materials are playing an important role in Laser Ablation Quadrupole Inductively Coupled Plasma-Mass Spectrometry (LA-Q-ICPMS). However, the intensive applications in LA-Q-ICPMS are restrained due to the lack of research on synthetic methods of geological standard glass materials. In this paper, the method of high-temperature fusion was chosen to synthesize standard andesite glass (GSR-2G) by using national standard andesite powder (GSR-2). Three effect factors of time, temperature and quenching were studied to ascertain homogeneity. Results show that the homogeneity of andesite glass is optimal when the synthetic temperature is 1300 ℃ for 4 hours and the andesite glass is quenched by liquid nitrogen. Therefore, andesite glass can be used as an internal standard material for microprobe analysis. The relative deviations of 35 trace elements and 10 major elements were less than 10% for GSR-2G andesite glass by using 193 nm ArF LA-Q-ICPMS. The relative deviations of measured values obtained for 35 trace elements from 7Li to ²³⁸U by chemical method (SN-Q-ICPMS) and LA-Q-ICPMS were generally better than 10%. The results obtained by Electron Microprobe Analysis (EMPA) for 10 major elements from ²³Na to ⁵⁶Fe were consistent with these by LA-Q-ICPMS. The obtained average values of 40 elements by LA-Q-ICPMS can be used as primary reference values for andesite glass of GSR-2G.