Abstract: A method for the determination of high-content of lithium in natural saturated brines by inductively coupled plasma-atomic emission spectrometry (ICP-AES) was developed. The sample was directly determined by ICP-AES with sample dilution factor of 10. The interference from matrix elements on Li determination was studied and matrix marching method was used for matrix effect correction. The detection limit of the method for Li was 1.02 mg/L and recoveries was the ranged of 97.4% to 101.5% with the precision of 1.21% RSD (n=12). The method has been applied to the determination of Li in natural saturated brine with advantages of good accuracy and high efficiency.