Abstract: At present, the management and quality control systems for geochemical sample analysis are mostly stand-alone programs. This paper discussed a system of geochemical sample analysis and quality monitoring, which was based on Net framework 3.5 and with Microsoft Visual Studio 2005 as its development tool, technology of ADO and Microsoft SQL server 2005 as database. The system can be divided into two subsystems. One is the subsystem for management and quality control of geochemical sample analysis, which based on C/S architecture. And the other one is the subsystem for the download of analysis tasks and the upload of analysis results, which based on B/S architecture. All the functions,such as sample receiving, sample re-numbering, assignment of the tasks,data upload and quality control, were achieved in this system. The core features of the system are management of the tasks and data, quality monitoring and control during the process of sample analysis. The preliminary results show that the system completes the data transmission and processing accurately, and each functional module works well and meets the design requirements.