Abstract: 44 kinds of elements in underground water were simultaneously analyzed by inductively coupled plasma-mass spectrometry (ICP-MS), which only took about 2~3 minutes for each sample. The detection limits of the method for the analytes were in the range of 0.002~0.981 μg/L and the recoveries were 90.0%~110.0% with precision of lower than 10% RSD (n=10) for most of the elements, which satisfied the technical standard requirements of quality control for inorganic analysis in underground water quality survey. The method provides the advantages of low detection limits, high precision and accuracy, high efficiency and has been successfully applied to routine analysis of these elements in groundwater samples.