Abstract: The paper briefly reviewed the development history of Multi-purpose Regional Geochemical Survey (MRGS) and Ecosystem Geochemistry Assessment (EGA) in China, and pointed out the main technical progress in sample analysis and analytical quality control achieved over the past decade. It was demonstrated that geochemical analysis will face great opportunities and challenge with the EGA is becoming the emphasis and focus of the MRGS study. To keep up with the requirements from regional mapping and eco-geochemical assessment, new measurement techniques and methods with higher accuracy and high precision need to be developed. Also a systematic analytical methodologies need to be established in order to meet the demands from multi-medium analysis and multi-index analysis.