Abstract: A method for direct determination of Mo, Pb, FeandCu in molybdenum ores by energydispersive X-ray fluorescence spectrometry was established. The effects of sample granularity and mineral properties on the determination were studied. Pressed pellet sample preparation method was used and the calibration curves were made by using standard samples. The matrix effect was eliminated y using interference factors calculated from the relevant elements. The precision and accuracy of the method were evaluated by analysis of he inner control standard samples. The results from the analysis of these elements in molybdenum ores were in agreement with those provided by the classical chemical methods with precision of 0.44%~15.4%RSD(n=11). This method is suitable for routine analysis.